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In a very the latest review, we noted the identification along with the characterization of a different atypical opioid receptor with exceptional unfavorable regulatory properties to opioid peptides.1 Our success confirmed that ACKR3/CXCR7, hitherto referred to as an atypical scavenger receptor for chemokines CXCL12 and CXCL11, can be a broad-spect